Published:  Jun 29, 2018DOI: 10.7324/JAPS.2018.8612
Organophosphate (OP) compounds are commonly used as pesticides in agriculture, in homes, offices and gardens, parasiticides in veterinary medicine, and also employed as chemical warfare agents (CWA). However, extensive application of these OPs within agricultural proximity leads to the deleterious effects on inhabiting fauna. This study was aimed to find out acute toxicity and elucidates the sub-lethal effect of commercially formulated organophosphate chlorpyrifos (CPF) on Duttaphrynus melanostictus tadpoles. In this study, the 96 h LC50 value found to be 5.9 mg/L. Tadpoles exposed to three sub-lethal concentrations (0.7, 1.1, and 1.9 mg/L) of CPF showed a significant (p < 0.05) alterations in enzymatic antioxidants like catalase, superoxide dismutase glutathione peroxidase and non-enzymatic malondialdehyde, further the anticholinesterase potential of CPF was evident in concentration-dependent trend at five days of exposure tenure. It could be therefore emphasized that the CPF poses a potential threat to D. melanostictus tadpoles under the selected concentrations and hence it is advised that care should be taken when the toxicant is used and disposed under aquatic proximity. The investigation further serves as the preliminary data in the due course of regulatory surveillance and could be of a greater help in monitoring water with suspected CPF contamination.
David M, Kartheek RM, Manjunath GP. Acute and sublethal toxicity of chlorpyrifos on developmental stages of Dattaphrynus melanostictus. J App Pharm Sci, 2018; 8(06): 087-093.
419 Absract views 11 PDF Downloads 430 Total views
Evaluation of the Antioxidant and Anti-Cholineesterase activities of the Stem, Barks and Leaves of the Plant Vernonia Cinerea (Family: Asteraceae)Md. Ahsanul Haque, Chowdhury Sayef Abdullah, Md Musfizur Hassan, Most. Nazma Parvin, Md. Bodruddoza Rafique, A.G.M. Mostofa
Effect of thyroid stimulating hormone on the ultrastructure of the thyroid gland in the Mexican axolotl during metamorphic climax
Suppressive effect of Ginkgo biloba extract (EGb 761) on topsin induced ovarian toxicity and oxidative stress in albino rats