Research Article | Volume: 8, Issue: 4, April, 2018

Physical Signs of Illness, Liver Functions and Reproductive Parameters of Female Rats Supplemented with Melaleuca cajuputi Methanolic Extract

Dzulsuhaimi Daud Nur Lisma Ruhila Alias Mohd Tajudin Mohd Ali Alene Tawang   

Open Access   

Published:  Apr 29, 2018

DOI: 10.7324/JAPS.2018.8420
Abstract

Melaleuca cajuputi is the main source of cajuput essential oil, which is widely used in the folk medicine in southeastern Asia. The study aimed to determine the effect of M. cajuputi methanolic extract (MCME) on liver functions and fertility of female Sprague Dawley rats. Twenty four female rats were divided into four groups and supplemented with 2 ml/kg bwt distilled water or several doses of MCME (50, 100, and 200 mg/kg bwt) for 30 days. Physical signs of illness were observed on a daily basis. Blood was collected at the end of the experimental period for liver functions and estrogen assay. All females also subjected to fertility test. No signs of illness and mortality were observed. Results also demonstrated that liver functions, estrogen level and fertility in female Sprague Dawley rats were not affected by MCME. These findings suggested that MCME at doses in between 50-200 mg/kg bwt were not toxic to female Sprague Dawley rats.


Keyword:     Melaleuca cajuputi toxicity liver functions estrogen assay in-vivo fertilization.


Citation:

Daud D, Alias NLR, Ali MTM, Tawang A. Physical Signs of Illness, Liver Functions and Reproductive Parameters of Female Rats Supplemented with Melaleuca cajuputi Methanolic Extract. J App Pharm Sci, 2018; 8(04): 139-142.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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