Short Communication | Volume: 8, Issue: 2, February, 2018

In vitro Anthelmintic Activity of Acanthus ilicifolius Leaves Extracts on Ascaridia galli and Pheretima posthuma

Dadang Irfan Husori Sumardi Heron Tarigan Selviani Gemasih Sri Rahayu Ningsih   

Open Access   

Published:  Feb 27, 2018

DOI: 10.7324/JAPS.2018.8224
Abstract

Parasitic worms in the chicken gastrointestinal tract are a chronic problem that becomes one of the causes of economic losses in the poultry. The aim of the study was to evaluate the anthelmintic activity of Acanthus ilicifolius leaves extract against Ascaridia galli and Pheretima posthuma. In vitro anthelmintic activity test was performed using 3 concentrations (15, 20, and 25 mg/ml) of ethanol, aqueous, and n-hexane extract of Acanthus ilicifolius leaves against Ascaridia galli and Pheretima posthuma. Pyrantel pamoate used as positive control, while the negative control using normal saline and distilled water. The vehicle control using carboxymethyl cellulose. The time to paralyze and time to death of worms were observed as anthelmintic activity parameter. The study also conducted phytochemical screening of the extract. The ethanol, aqueous and n-hexane of Acanthus ilicifolius leaves extracts of 15, 20, and 25 mg/ml concentration showed anthelmintic activity in Ascaridia galli and Pheretima posthuma. Anthelmintic activity was dose-dependent manner. Meanwhile, the results of phytochemical screening showed the three types of extracts contained secondary metabolites such as alkaloids, flavonoids, tannins, saponins and steroids. The ethanol, aqueous and n-hexane extracts of Acanthus ilicifolius leaves possessed anthelmintic activity against worms Ascaridia galli and Pheretima posthuma.


Keyword:     AnthelminticAcanthusilicifoliusAscaridia galliPheretima posthumapyrantelpamoate.


Citation:

Husori DI, Sumardi, Tarigan H, Gemasih S, Ningsih SR. In vitro Anthelmintic Activity of Acanthus ilicifolius Leaves Extracts on and Pheretima posthuma. J App Pharm Sci, 2018; 8(02): 164-167. Ascaridia gall and Pheretima posthuma. J App Pharm Sci, 2018; 8(02): 164-167.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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