Review Article | Volume: 8, Issue: 2, February, 2018

Design of buccal mucoadhesive tablets: understanding and development

Laisa Lis Fontinele de Sá ,  ,  Naiane Carvalho Nogueira,  Edson Cavalcanti Da Silva Filho,  Ana Figueiras,  Francisco Veiga,  Lívio César Cunha Nunes,  José Lamartine Soares-Sobrinho   
Laisa Lis Fontinele de Sá1 , 2, Naiane Carvalho Nogueira2, Edson Cavalcanti Da Silva Filho3, Ana Figueiras4, Francisco Veiga4, Lívio César Cunha Nunes2, José Lamartine Soares-Sobrinho1

1Núcleo de Controle de Qualidade de Medicamentos e Correlatos, Universidade Federal de Pernambuco, Recife, PE, Brazil.

2Laboratório de Inovação Tecnológica e Empreendorismo, Universidade Federal do Piauí, Teresina, PI, Brasil.

3Laboratório de Ciências dos Materiais, Teresina, PI, Brasil.

4Laboratório de Tecnologia Farmacêutica, Faculdade de Farmácia, Universidade de Coimbra.

Open Access   

Published:  Feb 27, 2018

DOI: 10.7324/JAPS.2018.8223
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Abstract

Mucoadhesive tablets for administration in buccal mucosa are unconventional formulations with many technological attractions. However there is no standardization of information for its formulation. The present article aims to evaluate, by means of a systematic review with meta-analysis, the data related to the final quality of this technology. The development of oral tablets with 100 to 150 mg, including soluble drugs and sustained release for 6 hours or more, is a consensus. The most frequent polymers used are those derived from cellulose, Carbopol (CBM), Chitosan (CS), and Gums, alone or blended, with adhesive strength in the order: CBM > Alginates > cellulose derivatives > Gums. Among other results, this article demonstrates that this technology depends on a detailed analysis between the polymer, the physical characteristics of the tablet, the physicochemical characteristics of the drug to be incorporated and the buccal region in which it will remain in contact.


Keyword:     Mucoadhesive tablets technological development buccal administration bioadhesion mucoadhesive polymers sustained release.

Citation:

de Sá LLF, Nogueira NC, Filho ECDS, Figueiras A, Veiga F, Nunes LCC, Soares-Sobrinho JL. Design of buccal mucoadhesive tablets: understanding and development. J App Pharm Sci, 2018; 8(02): 150-163.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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