Research Article | Volume: 8, Issue: 2, February, 2018

Antibacterial Activity of Indonesian Sponge Associated Fungi Against Clinical Pathogenic Multidrug Resistant Bacteria

Mada Triandala Sibero Ocky Karna Radjasa Agus Sabdono Agus Trianto Desy Wulan Triningsih Inggrid Debora Hutagaol   

Open Access   

Published:  Feb 27, 2018

DOI: 10.7324/JAPS.2018.8214

Exploration of new source of antibiotics to combat multidrug-resistant bacteria is urgently needed. Indonesia as archipelago country has a wide variety of marine organisms with potential as source of new antibacterial compounds against MDRO. Aims of the study were to isolate sponge-associated fungi from sponge Cinachyrella sp. collected from Pandang Island, North Sumatera, Indonesia, to screen potential fungi against clinical pathogenic MDR bacteria, to identify the potential fungi; and to determine the best cultivation time for antibacterial production. Nine sponge-associated fungi were successfully isolated. Result of agar plug method showed fungus PDSP 5.7 was the most potential candidate which inhibited ESBL Escherichia coli, Salmonella enterica ser. Typhi, MRSA, and Staphylococcus haemolyticus strain MDR. This fungus had 100% similarity to Trichoderma reesei. In malt extract broth, T. reesei PDSP 5.7 had stationary phase from day 12 to day 18. In addition, the widest antibacterial was performed by extract from day 15. Furthermore, fungal extract showed best antibacterial activity against S. enterica ser. Typhi strain MDR with inhibition value of 14.72 ± 0.07 mm2.

Keyword:     Antibacterial associatedfungi MDR Trichoderma.


Sibero MT, Radjasa OK, Sabdono A, Trianto A, Triningsih DW, Hutagaol ID. Anti-multidrug-resistant activity from fungi associated with sponge Cinachyrella sp. J App Pharm Sci, 2018; 8(02): 088-094.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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