Research Article | Volume: 8, Issue: 2, February, 2018

Anti-inflammatory and antioxidant activity of salicylic acid conjugated dihydropyrazoline analogues

Naveen Puttaswamy Rekha N D Lakshmi Ranganatha V Prashanth T Shaukath Ara Khanum   

Open Access   

Published:  Feb 27, 2018

DOI: 10.7324/JAPS.2018.8209
Abstract

Syntheses of substituted salicylic acid appended pyrazoline analogues (7a-j) via 1,3-dipolar cycloaddition were reported earlier. In the present investigation we have performed the anti-inflammatory activity by phospholipase A2 (PLA2) inhibition and in vitro antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl, nitric oxide, hydroxyl radical scavenging assay and ferrous ion chelating assay wherein compounds 7d, 7h, 7i and 7j have shown maximum anti-inflammatory activity. Further, compounds 7d, 7f and 7h were proved to be excellent free radical scavengers.


Keyword:     13-dipolar cycloadditionanti-inflammatory anti-oxidantphospholipase A2.


Citation:

Puttaswamy N, Rekha ND, Lakshmi Ranganatha V, Prashanth T, Khanum SA. Anti-inflammatory and antioxidant activity of salicylic acid conjugated dihydropyrazoline analogues. J App Pharm Sci, 2018; 8(02): 060-064.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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