Research Article | Volume: 8, Issue: 2, February, 2018

Anti-inflammatory and antioxidant activity of salicylic acid conjugated dihydropyrazoline analogues

Naveen Puttaswamy Rekha N D Lakshmi Ranganatha V Prashanth T Shaukath Ara Khanum   

Open Access   

Published:  Feb 27, 2018

DOI: 10.7324/JAPS.2018.8209
Abstract

Syntheses of substituted salicylic acid appended pyrazoline analogues (7a-j) via 1,3-dipolar cycloaddition were reported earlier. In the present investigation we have performed the anti-inflammatory activity by phospholipase A2 (PLA2) inhibition and in vitro antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl, nitric oxide, hydroxyl radical scavenging assay and ferrous ion chelating assay wherein compounds 7d, 7h, 7i and 7j have shown maximum anti-inflammatory activity. Further, compounds 7d, 7f and 7h were proved to be excellent free radical scavengers.


Keyword:     13-dipolar cycloadditionanti-inflammatory anti-oxidantphospholipase A2.


Citation:

Puttaswamy N, Rekha ND, Lakshmi Ranganatha V, Prashanth T, Khanum SA. Anti-inflammatory and antioxidant activity of salicylic acid conjugated dihydropyrazoline analogues. J App Pharm Sci, 2018; 8(02): 060-064.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
403 Views 40 Downloads 443 Total

Year

Month

Related Search

By author names