Review Article | Volume : 1 Issue : 9, November 2011

Niosomal Drug Delivery System: The Magic Bullet

Rajesh Mujoriya Ramesh Babu Bodla Kishor Dhamande Devendra singh Lokesh Patle   

Open Access   

Abstract

The concept of drug targeting or site specific drug delivery was introduced first time by Paul Elrich in 1909, when he reported ‘magic bullet’ to deliver a drug to the desired site of action without affecting the non target organs or tissues (Juliano, 1980) by associating the drug with a pharmacologically “inactive carrier” capable of conveying the drug selectively towards its target cells. The methods of preparation of niosomes such as hand shaking, ether injection and sonication (developed on the basis of liposome production technique) have been reviewed by Khandare et al., 1994. The hand shaking method form vesicles with greater diameter [0.35 – 13??m] as compared to those prepared by ether injection method [50-1000nm]. The film formation method was used for the preparation of the niosomes due to simplicity, reproducibility and high drug entrapment efficiency.


Keyword:     Magic bullet hand shaking ether injection sonication film formation method.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
406 Views 30 Downloads 436 Total

Year

Month

Related Search

By author names