Research Article | Volume: 8, Issue: 1, January, 2018

Hibiscus sabdariffa Linn. improves the aortic damage in diabetic rats by acting as antioxidant

Satirah Zainalabidin Siti Balkis Budin Nur Najmi Mohamad Anuar Nur Afizah Yusoff Nur Liyana Mohammed Yusof   

Open Access   

Published:  Jan 28, 2018

DOI: 10.7324/JAPS.2018.8116
Abstract

Chronic hyperglycaemia produces excessive free radicals which could lead to diabetic complications. Hibiscus sabdariffa Linn. is proven to have high antioxidant and antihyperlipidemic properties. The aim of the study was to investigate the effects of H. sabdariffa polyphenol-rich extract (HPE) in the aorta of diabetic rats. Twenty-four male rats were randomly divided into three groups, i.e. non-diabetes mellitus (NDM), diabetes mellitus (DM) and diabetes mellitus with HPE (DM + HPE). HPE at 100 mg/kg or saline as control vehicle were administered daily through oral gavage for 28 days prior to sacrification and the aorta was isolated for further analysis. The glucose level in DM + HPE was significantly lower compared to DM, indicating its potential as an antidiabetic agent. Conversely, catalase (CAT), superoxide dismutase (SOD) activity and the level of glutathione (GSH) in DM + HPE were significantly higher than DM. The level of malondialdehyde (MDA) and protein carbonyl were significantly lower in DM + HPE than DM. Lipid profile analysis demonstrated a significant decrease in triglyceride, total cholesterol and LDL-C in DM + HPE compared to DM, however, HDL-C was significantly increased. Microscopic observation showed a disrupted morphology of the thoracic aorta in diabetic rats. HPE may exert protective effects by acting as an antidiabetic, antihyperlipidemic and antioxidant agent to the thoracic aorta in diabetic rats.


Keyword:     Antioxidant diabetesfree radical Hibiscus sabdariffa Linnoxidative damage .


Citation:

Zainalabidin S, Budin SB, Anuar NNM, Yusoff NA, Yusof NLM. Hibiscus sabdariffa Linn improves the aortic damage in diabetic rats by acting as antioxidant. J App Pharm Sci, 2018; 8 (01): 108-114.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
462 Views 30 Downloads 492 Total

Year

Month

Related Search

By author names