Published:  Dec 30, 2017DOI: 10.7324/JAPS.2017.71210
Background: There are raised concerns regarding the rational guidelines-based prescribing of proton pump inhibitors (PPIs) therapy in the hospital setting.
Objective: To describe the current prescribing practice of PPIs among hospitalized patients in non-intensive care settings. Also, the study aimed to evaluate the appropriateness of the prescribed PPIs.
Methods: A cross-sectional study was conducted in the medical ward of a tertiary hospital in the state of Pahang, Malaysia. A total of 153 medical records of non-critically-ill adult patients receiving PPI therapy were investigated. The assessment of PPI prescribing was performed referring to clinical guidelines and the list of PPI-approved indications.
Results: The most frequently prescribed PPI regimen has been pantoprazole 40 mg OD. Approximately 34% of the prescribed regimens were considered to be appropriate as it was consistent with the clinical guidelines. However, about 31% of the prescribed PPIs did not have a clear indication. Moreover, the inappropriate use of PPIs was revealed in nearly 19% of the total PPIs prescriptions. Finally, 16% of the prescribed PPIs were in need of dosage adjustment due to the presence of drug-drug interactions with the concurrently used medications.
Conclusion: Inappropriately prescribed PPIs are prevalent among non-critically ill-hospitalized adult patients in a Malaysian tertiary hospital. Initiatives for enforcing rational prescribing should focus on the proper documentation of evidence-based indications of PPIs in the medical records. There is a desperate need in the local setting for well-defined PPIs prescribing criteria. Future research should design and examine the impact of prescribing improvement interventions on the PPIs rational prescribing.
Elnaem MH, Mohamed MH, Nazar AH, Ibrahim RNK. Evaluation of Proton Pump Inhibitors Prescribing among Non-Critically Ill Hospitalized Patients in a Malaysian Tertiary Hospital. J App Pharm Sci, 2017; 7 (12): 077-083.
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