Research Article | Volume: 7, Issue: 12, December, 2017

Crushed Puffed Rice-HPMC-Chitosan based Single-Unit Hydro-dynamically Balanced System for the Sustained Stomach Specific Delivery of Metoprolol Succinate

Shashank Soni Veerma Ram Anurag Verma   

Open Access   

Published:  Dec 30, 2017

DOI: 10.7324/JAPS.2017.71206
Abstract

Purpose: Developed and evaluated a Hydrodynamically Balanced System (HBS) capsule system using natural and novel biodegradable polymer used as Crushed Puffed Rice (CPR) alone and in combination with auxiliary polymers (High Molecular Weight Chitosan; HMWCH and Hydroxypropyl methylcellulose; HPMC K15) for stomach specific delivery.ï¾

Method: A total of nine formulations was prepared by manual shaking method and filled in colorless hard capsule shell size 1. The prepared capsule was evaluated for parameters such as drug content, in vitro buoyancy and drug release in 0.1M HCl, drug delivery kinetics.ï¾

Results: Average floating time for the formulation is 08 hours. CPR is used as a buoyancy imparting agent due to its floating behavior; it floats in 0.1 M HCl (pH 1.2) and remained unwetted for the time period of 05 hours. CPR, HPMC K15, and HMWCH have a significant effect (p


Keyword:     Biodegradable polymerCrushed puffed riceHydrodynamically Balanced SystemMetoprolol SuccinateZero order kinetics model.


Citation:

Soni S, Ram V, Verma A. Crushed Puffed Rice-HPMC-Chitosan based Single-Unit Hydro-dynamically Balanced System for the Sustained Stomach Specific Delivery o

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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