Research Article | Volume: 7, Issue: 11, November, 2017

Spectrophotometric Determination of pKa and Log P of Risperidone

Sunil Kumar DubeyGautam SinghviAbhay TyagiHimanshu AgarwalK. V. Krishna   

Open Access   

Published:  Nov 30, 2017

DOI: 10.7324/JAPS.2017.71123
Abstract

Objective: Determination of pKa and Log P of Risperidone by spectrophotometric technique.
Materials and Methods: From the perspective of dosage form design and pharmaceutical analysis, the dissociation constant and partition coefficient are the most important physicochemical properties of a drug which need to be determined. The pKa determination of Risperidone was carried out using a simple UV–Visible spectrophotometric method and Log P was estimated using shake flask method followed by UV analysis.
Results and Conclusion: Experimental value of pKa and log P for Risperidone, an anti-psychotic drug, has been reported for the first time. The pKa value of Risperidone was found to be 8.62 and log P of Risperidone was estimated to be 3.50.


Keyword:     Anti-psychoticDissociation constantPartition coefficientValidation.


Citation:

Dubey SK, Singhvi G, Tyagi A, Agarwal H, Krishna KV. Spectrophotometric Determination of pKaand Log P of Risperidone. J App Pharm Sci, 2017; 7 (11): 155-158.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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