Research Article | Volume: 7, Issue: 9, September, 2017

Antifibrotic candidates of Selenium nanoparticles and selenium in the experimental model

Aziza B. Shalby Mohamed Diaa Abd El-Maksoud Ahmed E. Abdel Moneim Hanaa H. Ahmed   

Open Access   

Published:  Sep 30, 2017

DOI: 10.7324/JAPS.2017.70926
Abstract

This research was designed to compare the efficacy of selenium in nanoscale (SeNPs) with its free form (Se) against liver fibrosis induced by thioacetamide (TAA) in rats. In a completely randomized design, 60 adult female rats were distributed as: Group (1) control (received saline) and other three groups received TAA to induce liver fibrosis (100 mg/kg b.wt of three times a week for 6 weeks). Fifteen rats were termed TAA (Group 2). Rats in group (3) were simultaneously administered SeNPs (0.48 mg/kg/b.wt) orally (TAA+SeNPs). Rats in group (4) were simultaneously administered Se (0.48 mg/kg/b.wt) orally (TAA+Se). TAA injection enhanced liver enzymes activity, oxidative stress markers and inflammatory mediators, while suppressed the activity of the antioxidant enzymes activity versus the control group. SeNPs as well as Se supplementation blunted liver enzymes activity, oxidative stress indicators and inflammatory intermediates, while potentiated the activity of the antioxidant enzymes relative to TAA group. Histological investigation of liver tissue appreciated the biochemical findings. Aforementioned data clearly indicate that the mitigation of oxidative stress and inflammation may be the probable mechanisms by which SeNPs or Se can offer their antifibrotic action. Worth mentioning, SeNPs showed superior effect above Se in its free form in this respect.


Keyword:     Selenium nanoparticles Liver fibrosis Inflammation Antifibrotic action Rats.


Citation:

Shalby AB, El-Maksoud MA, Moneim AE, Ahmed HH. Antifibrotic candidates of Selenium nanoparticles and selenium in the experimental model. J App Pharm Sci, 2017; 7 (09): 191-198.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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