Published:  Aug 30, 2017DOI: 10.7324/JAPS.2017.70831
Green synthesis of silver nanoparticles using Caesalpinia gilliesii (Hook) leaves extract (70% MeOH) for the first time as a reducing agent were investigated for their antimicrobial and cytotoxic activity (using the MTT assay). After exposing the oxidizing agent of silver ions to C. gilliesii leaves extract, the rapid reduction in the solution is observed due to the construction of silver nanoparticles. The prepared nanoparticles were elucidated by using UV-visible spectroscopy, Fourier Transforms infrared spectroscopy (FT-IR) and transmission electron microscope (TEM). The purified silver nanoparticles demonstrated promising antimicrobial activity against tested pathogens than hydroalcoholic extract. Cell viability by using the MTT assay demonstrated cytotoxic activity of the synthesized Ag NPs with C. gilliesii against normal skin fibroblast (BJ-1) and human breast cancer cell (MCF-7) with IC50= 80.1 and 36.5 ðœ‡g/mL at 48 hours incubation, respectively. Depending on the phenolic and flavonoid contents, C. gilliesii could be used for simple, nonhazardous, eco-friendly, cost-effective and efficient synthesis of Ag NPs that can be applied into medicinal field.
Emam M, El-Raey MA, Eisa WH, El-Haddad AE, Osman SM, ElAnsari MA, Rabie AM. Antimicrobial of Green Synthesis Silver Nanoparticles Using Extract of Caesalpinia gilliesii (Hook) leaves: and in Vitro Cytotoxic Effect against BJ1 and MCF-7 Cells. J App Pharm Sci, 2017; 7 (08): 226-233.
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