Research Article | Volume: 7, Issue: 8, August, 2017

Antidiabetic and antihyperlipidemic activity of Euphorbia thymifolia L. extracts on streptozotocin-nicotinamide induced type 2 diabetic rats

Ghanshyam R. Parmar Kilambi Pundarikakshudu R. Balaraman   

Open Access   

Published:  Aug 30, 2017

DOI: 10.7324/JAPS.2017.70811
Abstract

The present investigation is aimed to elucidate the hypoglycaemic and hypolipidemic effect of the aqueous and methanol extract of Euphorbia thymifolia (ET) aerial parts in streptozotocin-nicotinamide (STZ-NA) induced diabetic rats. Diabetes was induced by administration of STZ (65 mg/kg, i.p.) followed by NA (110 mg/kg i.p.) 15 min later. The diabetic rats were treated with aqueous and methanol extract from ET (250 and 500 mg/kg, p.o., respectively) for 28 days. Fasting blood glucose level, plasma insulin, HbA1c, urea, serum creatinine, lipid profile, liver glycogen, ALP, total protein and histopathology of pancreas were carried out to assess antidiabetic and antihyperlipidemic effect. After treatment with ET extracts fasting blood glucose, HbA1c levels, urea, serum creatinine and total protein were significantly decrease in diabetic rats. However, serum insulin level and liver glycogen were significantly increased in diabetic rats. The extracts also exhibited a significant hypolipidemic effect as evident from fall in total cholesterol, triglycerides, low-density lipoproteins and increase high-density lipoproteins level. The histopathological studies of the pancreas in extract treated diabetic groups revealed almost normal appearance. This study supports the traditional proclamations on E. thymifolia aerial parts.


Keyword:     Euphorbia thymifolia streptozotocin-nicotinamide plasma insulin lipid profile.


Citation:

Parmar GR, Pundarikakshudu K, Balaraman R. Antidiabetic and antihyperlipidemic activity of Euphorbia thymifolia L. extracts on streptozotocin-nicotinamide induced type 2 diabetic rats. J App Pharm Sci, 2017; 7 (08): 078-084.

Copyright: © The Author(s). This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
448 Views 59 Downloads 507 Total

Year

Month

Related Search

By author names