Review Article | Volume: 7, Issue : 4, April, 2017

Effect of Nigella sativa supplementation on human lipids: systematic review

Redhwan Ahmed Al-Naggar Muhamed T. Osman Isa Naina Mohamed Khairun Nain Bin Nor Aripin Mahfoudh A. M. Abdulghani   

Open Access   

Published:  Apr 30, 2017

DOI: 10.7324/JAPS.2017.70432

Nigella sativa (NS) is widely used in traditional medicine and several studies have been conducted to reveal NS effects on different medical disorders including hyperlipidemia. Since hyperlipidemia is a common risk factor for the development of cardiovascular illness. We evaluated the effects of NS supplementation on lipid profile in clinical trial performed among humans. A search on published studies was done by using databases including Scopus, PubMed, Google Scholar, Thomas Reuters Web of Science, and CINAHIL. Terms searched included “Nigella sativa, Black seed, Black cumin, Triglycerides, Cholesterol, Lipoproteins”. Initially 432 articles were extracted. However, four hundred eighteen papers were unrelated, reviews, animal studies, combined and duplicated studies were excluded, and finally only fourteen articles were eligible for this review. After analysing 14 articles including 738 participants from different countries and nations. Results of these clinical trials revealed that Nigella sativa is effective to change the lipid profile significantly in different conditions. This systematic review revealed that Nigella sativa supplementation might be effective in hyperlipidemic control in humans and seems potential target of future drug for hyperlipidemic conditions.

Keyword:     Nigella sativa black seeds hyperlipidemia human lipids lipid profile.


Al-Naggar RA, Osman MT, Mohamed IN, Aripin KNB, Abdulghani MAM. Effect of Nigella sativa supplementation on human lipids: systematic review. J App Pharm Sci, 2017; 7 (04): 213-219.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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