Research Article | Volume: 7, Issue: 7, July, 2017
Research Article | Volume: 7, Issue: 7, July, 2017
Gout is a form of inflammatory arthritis caused by the deposition of uric acid. The therapeutic approach to gout is mainly divided by the treatment of inflammation and the management of serum urate level. This study aim to investigate whether chondroitin sulfate (CS) and glucosamine in chicken feet cartilage powder (CFE) and aqueous extract (AE) are able to decrease serum urate level and inflammation in animal model of gouty arthritis. CFE and AE were evaluated in vitro for xanthine oxidase (XO) inhibition. The anti-hyperuricemic activity and liver XO inhibition were evaluated in vivo on oxonate-induced hyperuricemia rats. Anti-inflammatory property was also determined on monosodium urate (MSU) crystal-induced paw edema model. CFE and AE supplementation showed urate-lowering activity. However, both treatments were not able to inhibit in vitro and in vivo XO activity. In MSU crystal-induced mice, the levels of paw swelling and lipid peroxidation were increased; in addition, a decrease in the activities of SOD and changes in the expression of CD11b+TNF-α and CD11b+IL-6 of the spleen were demonstrated. These changes were reverted to near normal levels upon CFE and AE treatments. These results suggest that CS and glucosamine from CFE and AE show a potent therapeutic effect against gouty arthritis.
Widyaningsih TD, Putri WD, Murtini ES, Rochmawati N, Nangin D. Anti-inflammatory and anti-hyperuricemia properties of chicken feet cartilage: treatment on gouty arthritis animal model. J App Pharm Sci, 2017; 7 (07): 202-207.
Year
Month
Effect of the fractions of Erythrina stricta leaf extract on serum urate levels and Xo/Xdh activities in oxonate-induced hyperuricaemic mice
Remya Raju, Sigimol Joseph, Soniya Scria, Santhosh M Mathews, M. UmamheshwariKinetics of Inhibition of Xanthine Oxidase by Globularia alypum and its Protective Effect against Oxonate-Induced Hyperuricemia and Renal Dysfunction in Mice
Influence of Bacopa monnieri in suppressing the arthritis induced by MSU crystal in Wistar albino female rats: Through biochemical and histopathological approach
Jerine Peter Simon, Prajakta Subhash Gaopande, Swathika Praveen, Arjun Ajikumar Reeja, Abinaya Rajasekar, Radhakrishnan Vidya, Usha Kumari, Evan Prince SabinaStructure activity relationship studies of synthesised pyrazolone derivatives of imidazole, benzimidazole and benztriazole moiety for anti-inflammatory activity