Research Article | Volume: 7, Issue: 5, May, 2017

Antifungal activity of the essential oil isolated from Laurus nobilis L. against Cryptococcus neoformans strains

Lílian Sousa Pinheiro,  Abrahão Alves de Oliveira Filho,  Felipe Queiroga Sarmento Guerra,  Camilla Pinheiro de Menezes,  Socrates Golzio dos Santos,  Janiere Pereira de Sousa,  Tassiana Barbosa Dantas ,  Edeltrudes de Oliveira Lima   
Lílian Sousa Pinheiro1, Abrahão Alves de Oliveira Filho2, Felipe Queiroga Sarmento Guerra1, Camilla Pinheiro de Menezes1, Socrates Golzio dos Santos3, Janiere Pereira de Sousa1, Tassiana Barbosa Dantas1 , Edeltrudes de Oliveira Lima1

1Program in Natural Products and Synthetic Bioactive, Federal University of Paraiba, Paraiba, Brazil.

2Academic Unit Biological Sciences, Federal University of Campina Grande, Paraiba, Brazil.

3Research Institute for Drugs and Medicines, Federal University of Paraiba, Paraiba, Brazil.

Open Access   

Published:  May 30, 2017

DOI: 10.7324/JAPS.2017.70520
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Abstract

Cryptococcosis is an opportunistic fungal infection that evolved to an important cause of morbidity and mortality in recent years. Even with advances in medicine, the treatment of ringworm still presents a therapeutic system with limited availability of antifungal agents, and so, research is needed to identify new agents fungistatic or fungicides effectives. The natural products are known to represent an arsenal of compounds, some with antifungal properties. Thus, this study aimed investigates the antifungal activity in vitro of the essential oil of Laurus nobilis L. (leaves) against Cryptococcus neoformans strains. The chemical composition of the oil was analyzed by gas chromatography coupled to mass spectrometry (GC / MS) and minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were determined by the broth micro dilution techniques. The MIC100 of essential oil were 256 𝜇g/mL and the MFC50 was 1024𝜇g/mL. In conclusion the essential oil showed in vitro antifungal potential against strains of C. neoformans.


Keyword:     Essential oilantifungalCryptococcusLaurus nobilis.

Citation:

Pinheiro LS, Filho AAO, Guerra FQS, Menezes FP, Santos SG, Sousa JP, Dantas TB, Lima EO. Antifungalactivity of the essential oil isolated from Laurus nobilis L. against Cryptococcus neoformans strains. J App Pharm Sci, 2017; 7 (05): 115-118.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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