Objective: To evaluate the antimicrobial activity of different extracts of Hydroclathrus clathratus (C. Agardh) M. Howe against human bacterial and fungal pathogens.
Methods: The antimicrobial activities of the extracts against various pathogens were tested by using agar well diffusion method.
Results: Maximum activities were recorded by methanolic extract on P. aeruginosa (26.33±1.86mm), S.aureus (21.00±1.78mm), E. coli (19.32±0.89mm), B. subtilis (18.33±1.86mm) and K. Pneumoneae (18.14±1.50 mm). Hexane extract showed maximum antifungal activity against F. oxysporum (18.33±1.86mm) and ethyl acetate showed maximum activity against A. niger (18.33±2.73mm). While, methanolic extract showed more activity against A. flavus (18.00±3.22 mm), C. albicans (18.14±1.50mm) and Penicillium sp. (13.66±1.36mm). However, aqueous extract showed minimum inhibitory effect on the pathogens.
Conclusions: Different solvent extracts of seaweeds used in the present study have shown significant anti-bacterial and anti-fungal action. The study offers opportunities for producing new types of bioactive compounds; however, the mechanism of inhibition and stability of the extracts still are not clear and more studies should be involved.
Vimala T, Poonghuzhali TV. In vitro antimicrobial activity of solvent extracts of marine brown alga, Hydroclathrus clathratus (C. Agardh) M. Howe from Gulf of Mannar. J App Pharm Sci, 2017; 7 (04): 157-162.
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