Research Article | Volume : 1 Issue : 2, April 2011

Anti-Ulcerogenic Potential of Ficus bengalensis Leaf, Biochemical Parameter & Histopathological Study

Mayank Kulshreshtha Mradul Goswami Chandana V. Rao Vrish D Ashwlayan Sachdev Yadav   

Open Access   

Abstract

The effect of aqueous extract of Ficus bengalensis (FBE) was assessed in different acute and chronic gastric ulcer models in rats. Gastric ulcers induced in swiss albino rats (200g, N=6) by oral administration of aspirin suspension and pylorus ligation. The anti ulcer activity was assessed by determining and comparing the ulcer index in the test drug groups with that of the vehicle control and standard ranitidine & sucralfate. FBE, 250–500 mg/kg administered orally, twice daily for 5 days showed dose-dependent ulcer protective effect in pylorus ligation (51.28, 63.24% protection, P < 0.01 to P < 0.001), aspirin (28.94, 64.91 protection, P < 0.001). The parameters taken to assess antiulcer activity were pH of gastric juice, total acidity and ulcer index. The results indicated that aqueous extract significantly (p<0.05) Ph, total acidity and ulcer index. On the basis of histopathology analysis, The results indicate that FBE possesses antiulcer activity in a dose dependent manner.


Keyword:     Ficus bengalensis Pylorus ligation Acidity Ulcer index.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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