Research Article | Volume: 7, Issue: 3, March, 2017

Development of in situ Ophthalmic gel of Dexamethasone Sodium Phosphate and Chloramphenicol: A Viable Alternative to Conventional Eye Drops

Ketan Ranch Hetal Patel Laxman Chavda` Akshay Koli Furqan Maulvi Rajesh K. Parikh   

Open Access   

Published:  Mar 30, 2017

DOI: 10.7324/JAPS.2017.70316
Abstract

Context: Poor bioavailability (<10%) of drugs from conventional eye drops is mainly due to the various precorneal loss factors which include rapid tear turnover, systemic drug absorption through naso-lachrymal duct, transient residence time of the drug solution in the cul-de-sac and the relative impermeability of the drugs to corneal epithelial membrane.

Objective: The objective of present work was to develop sustain release in situ ophthalmic gel of dexamethasone sodium phosphate (DXM) and chloramphenicol (CHL) using experimental design.

Material and methods: Gellan gum (an ion sensitive polymer) in combination with carbopol 940 (pH sensitive polymer) were used as gelling agent. The developed formulations were characterized for clarity, pH, in vitro gelling capacity, viscosity, assay, in vitro drug release, mucoadhesive strength. Optimum formulation was selected based on validated quadratic polynomial equations developed using response surface methodology. Results and Discussion: The optimized formulation exhibited 0.2 N mucoadhesive strength; 4013 cps viscosity at physiological condition and 90% release of both drugs over a period of 10-12 hrs.

Conclusion: Mucoadhesive in situ gel for prolong ocular delivery of DXM and CHL was developed using 32 full-factorial experimental design. The developed stable formulation could be a viable alternative to conventional eye drops for treatment of endophtalmitis.


Keyword:     Full factorial design response surface methodology gellan gum dexamethasone sodium phosphate chloramphenicol.


Citation:

Ranch K, Patel H, Chavda L, Koli A, Maulvi F, Parikh RK. Development of in situ Ophthalmic gel of Dexamethasone Sodium Phosphate and Chloramphenicol: A Viable Alternative to Conventional Eye Drops. J App Pharm Sci, 2017; 7 (03): 101-108.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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