Research Article | Volume: 7, Issue: 2, February, 2017

Application of silver nanoparticles for the spectrophotometric determination of three benzimidazole anthelmintic drugs in their pharmaceutical preparations

Sayed M. Derayea Hassan Refat H. Ali Ahmed A. Hamad Ramadan Ali   

Open Access   

Published:  Feb 27, 2017

DOI: 10.7324/JAPS.2017.70209
Abstract

This article describes the application of silver nanoparticles (AgNPs) as a colorimetric probe for the simple and selective determination of three anthelmintic benzimidazole drugs namely; albendazole, flubendazole and mebendazole. The method was based on the AgNPs aggregation induced by their interaction with the cited drugs. This interaction produced a color change from yellow to blue and accompanied by the appearance of a new surface plasmon resonance peak of AgNPs measured in the range of 615 – 630 nm. The linear concentration ranges of the method were 2.0–9.0, 2.0–10 and 2.2–15 μg mL-1 (r2 = 0.9939, 0.9950 and 0.9938) for the studied drugs respectively. The validation of the analytical performance of the method was carefully investigated, and the results were satisfactory. This method was applied successfully to determine the three benzimidazoles in their pharmaceutical samples (tablets and suspensions) with high accuracy and precision. The suggested procedure is characterized by its simplicity since it does not involve solvent extraction or any critical reaction conditions.


Keyword:     Benzimidazoles Citrate-capped Silver nanoparticles Surface plasmon resonance UV-visible Spectrophotometry Pharmaceutical analysis.


Citation:

Derayea SM, Ali HRH, Hamad AA, Ali R. Application of silver nanoparticles for the spectrophotometric determination of three benzimidazole anthelmintic drugs in their pharmaceutical preparations. J App Pharm Sci, 2017; 7 (02): 076-082.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text

Reference

Article Metrics
382 Views 55 Downloads 437 Total

Year

Month

Related Search

By author names