Research Article | Volume: 7, Issue: 1, January, 2017

Synthesis and characterization of cobalt ferrites nanoparticles with cytotoxic and antimicrobial properties

Amal S. Hathout,  Abdulhadi Aljawish,  Bassem A. Sabry,  Aziza A. El-Nekeety,  Mohamed H. Roby,  Nasseralla M. Deraz,  Soher E. Aly,  Mosaad A. Abdel-Wahhab   
Amal S. Hathout1, Abdulhadi Aljawish2,3, Bassem A. Sabry1, Aziza A. El-Nekeety1, Mohamed H. Roby4, Nasseralla M. Deraz5, Soher E. Aly1, Mosaad A. Abdel-Wahhab1

1Food Toxicology & Contaminants Departmnt, National Research Center, Dokki, Cairo, Egypt.

2Nutrition Physiology and Toxicology Laboratory (NUTOX), INSERM U866, Bourgogne University, 1 Esplanade Erasme, F-21000 Dijon, France.

3ProBioGem Laboratory, EA 1026, Polytech'Lille-IUT "A" Bd Paul Langevin, Villeneuve d'Ascq cedex, Université Lille Nord de France, France.

4Food Science and Technology, Faculty of Agriculture, Fayoum University, Fayoum, Egypt.

5Physical Chemistry Department, National Research Center, Dokki, Cairo, Egypt.

Open Access   

Published:  Jan 31, 2017

DOI: 10.7324/JAPS.2017.70111
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Abstract

Recently, the application of nanotechnology in food sector and the agriculture attract the attention compared to its biomedical application. The aims of the current study was to synthesize and characterize cobalt ferrites nanoparticles [(CoFe2O4) NPs] by combustion method employing glycine as fuels and to evaluate their antimicrobial against pathogenic bacteria and fungi and anti cancer properties against MCF-7 breast cancer cells line. The results indicated that the particles size of the synthesized (CoFe2O4) NPs was 40 nm. These (CoFe2O4) NPs showed potential antibacterial properties against Gram-negative bacteria (Escherichia coli, Salmonella typhi) and Gram-positive bacteria (Staphylococcus aureus, Bacillus cereus) as well as the pathogenic fungi (Aspergillus flavus and Aspergillus ochraceus) in a dose dependent manner with maximum concentration of 1.8 mg/ml. (CoFe2O4) NPs also showed weak antiradical but have cytotoxic effects against MCF-7 breast cancer cells line and succeeded to decrease the cell viability at a concentration of 2 mg/ml. It could be concluded that (CoFe2O4) NPs is a promise candidate as antimicrobial and anticancer agent for food sector and medical application.


Keyword:     Food safety antimicrobial anticancer cobalt ferrites nanoparticles nanotechnology

Citation:

Hathout AS, Aljawish A, Sabry BA, El-Nekeety AA, Roby MH, Deraz NM, Aly SE, Abdel-Wahhab MA. Synthesis and characterization of cobalt ferrites nanoparticles with cytotoxic and antimicrobial properties. J App Pharm Sci, 2017; 7 (01): 086-092.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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