Research Article | Volume: 6, Issue: 8, August, 2016

A preliminary evaluation of anticancer and antioxidant potential of two traditional medicinal plants from Lamiaceae-Pogostemon heyneanus and Plectranthus amboinicus

Vaishali Rai Vinitha Ramanath Pai Pratapchandra Kedilaya   

Open Access   

Published:  Aug 30, 2016

DOI: 10.7324/JAPS.2016.60811
Abstract

This study investigates the cytotoxic and antioxidant potential of crude leaf extracts of Pogostemon heyneanus (P. heyneanus) and Plectranthus amboinicus (P. amboinicus), medicinal plants from Lamiaceae family. Crude leaf extracts, with methanol, ethanol and chloroform were evaluated for cytotoxicity in two breast cancer cell lines of different grades, MCF-7 and MDA-MB-231, by MTT assay. The antioxidant activity of the extracts was evaluated by DPPH and H2O2 assays. The results of MTT assay revealed that chloroform extract of P. heyneanus and ethanol extract of P. amboinicus were effective against MCF-7 cells. The chloroform extract of P. heyneanus was more effective than P. amboinicus against MDA-MB-231. Effective antioxidant activity was shown by the ethanol extract of P. amboinicus which correlated positively with the total phenol content. The chloroform extract of P. heyneanus, was rich in steroids and saponins which correlated positively with the cytotoxic activity. In conclusion, chloroform soluble leaf extracts of P. heyneanus, which is rich in steroids and saponins shows effective cytotoxicity on both breast cancer lines studied and could be used for identification of a potential anticancer principle, while ethanol extract of P. amboinicus has better potential as an antioxidant.


Keyword:     Pogostemon heyneanus Plectranthus amboinicus MCF-7 MDA-MB-231 Anticancer Antioxidant.


Citation:

Vaishali Rai, Vinitha Ramanath Pai, Pratapchandra Kedilaya. A preliminary evaluation of anticancer and antioxidant potential of two traditional medicinal plants from Lamiaceae - Pogostemon heyneanus and Plectranthus amboinicus. J App Pharm Sci, 2016; 6 (08): 073-078.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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