Research Article | Volume: 6, Issue: 7, July, 2016

Study the release kinetics of curcumin released from PVA/curcumin composites and its evaluation towards hepatocarcinoma

Doaa Essamey El-Nashar Nehad Naem Rozik Abdel Mohsen Soliman Fahima Helaly   

Open Access   

Published:  Jul 28, 2016

DOI: 10.7324/JAPS.2016.60710
Abstract

The polymer composites based on Polyvinyl alcohol loaded with different concentrations of commercial curcumin were prepared to be applied forcontrolled release drug delivery system to overcome the growth promotion of tumor cells. The prepared composites were subjected to drug release in aqueous media at room temperature. It was found that the amount of the released curcumin changed according to different pH media and the concentration of the loaded drug onto the polymer carrier. The diffusion coefficient of the released curcumin from the prepared composites was found to be 2.739X10-2, 1.638X10-2, and 5.777X10-4 in basic, acidic and neutral solution respectively according to Higuch's equation. The results of the in/vitro cytotoxic activity of the released curcumin showed sustained antiproliferative potency up to 30 % growth inhibition against the human liver cancer cell line (HEPG2) which extended to 25 days, to overcome hepatocarcinoma.


Keyword:     Curcumin Polyvinyl alcohol (PVA) slow release anticancer drug.


Citation:

El-Nashar DE, Rozik NN, Soliman AM, Helaly FM. Study the release kinetics of curcumin released from PVA/curcumin composites and its evaluation towards hepatocarcinoma. J App Pharm Sci, 2016; 6 (07): 067-072.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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