Research Article | Volume: 6, Issue: 6, June, 2016

Evaluation of Cytotoxic Activity of Sargassum vulgare From the Lebanese Coast Against Jurkat Cancer Cell Line

Mona Y. Tannourya,  Josiane M. Eliaa ,  Antoine M. Saabc,  Hassane Y. Makhloufb,  Jihad S. Abboudd,  Roula J. DaouChaboa,  Mona Diab-Assafb   
Mona Y. Tannourya, Josiane M. Eliaa , Antoine M. Saabc, Hassane Y. Makhloufb, Jihad S. Abboudd, Roula J. DaouChaboa, Mona Diab-Assafb

aDepartment of Bilogy, Faculty of Science II, Lebanese University, Lebanon.

bDoctoral School of Science and Technology, Lebanese University, Hadath, Lebanon.

cDepartment of Chemistry, Faculty of Science II, Lebanese University, Lebanon.

dDepartment of Animal Sciences, Faculty of Agriculture and Animal Sciences. Lebanese University, Lebanon.

Open Access   

Published:  Jun 28, 2016

DOI: 10.7324/JAPS.2016.60619
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Abstract

The discovery of cancer drugs that effectively destroy cancer cells or stop their growth without toxicity to normal cells is a challenge to enhance the therapeutic effects and reduce side effects. Many papers have highlighted the implication of marine algae that show anticancer activity. In this report, we assessed the cytotoxic activity of two different crude extracts from Sargassum vulgare (Sargassaceae), a marine brown algae collected from the Lebanese coast, against Jurkat human cancer cell line using trypan blue exclusion test. Both extracts, water: ethanol extract and chloroform: ethanol extract, showed cytotoxic activity against Jurkat cancer cell line with IC50 values of 136.907 µg/ mL and 49.056 µg/ mL, respectively after 72 hours of treatment. Further research designed to isolate and identify novel and efficient anticancer drug candidates from these seaweed extracts need to be explored.



Citation:

Tannoury MY, Elia JM, Saab AM, Makhlouf HY, Abboud JS, Daou-Chabo RJ, Diab-Assaf M. Evaluation of Cytotoxic Activity of Sargassum vulgare From the Lebanese Coast Against Jurkat Cancer Cell Line. J App Pharm Sci, 2016; 6 (06): 108-112.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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