Research Article | Volume: 6, Issue: 6, June, 2016
Pyrimidinethione derivatives with tosyl substitution: Synthesis, and antimicrobial property investigation
Research Article | Volume: 6, Issue: 6, June, 2016
Pyrimidinethione derivatives with tosyl substitution: Synthesis, and antimicrobial property investigation
Substitution of tosyl group on hydroxyacetophenones orhydroxybenzaldehyde and their subsequent condensation yielded several tosyloxy substituted chalcones which were derivatized to obtain the corresponding pyrimidinethione derivatives. The synthesized compounds were characterized by spectroscopic techniques like FT-IR, 1H NMR, 13C NMR, and mass spectrometry. These compounds were subjected to initial screening for their bioactivity using zone of inhibition method and were found moderately active against the tested microorganisms, viz. Mycobacterium smegmatis, Staphylococcus aureus, Escherichia coli, and Candida albicans.
Shubhalaxmi, Manjunatha BS, Ananda K, Subrahmanya Bhat K. Pyrimidinethione derivatives with tosyl substitution: Synthesis, and antimicrobial property investigation. J App Pharm Sci, 2016; 6 (06): 073-078.