Research Article | Volume: 6, Issue: 6, June, 2016

Pyrimidinethione derivatives with tosyl substitution: Synthesis, and antimicrobial property investigation

Shubhalaxmia B. S. Manjunathaa K. Anandab K. Subrahmanya Bhata   

Open Access   

Published:  Jun 28, 2016

DOI: 10.7324/JAPS.2016.60613
Abstract

Substitution of tosyl group on hydroxyacetophenones orhydroxybenzaldehyde and their subsequent condensation yielded several tosyloxy substituted chalcones which were derivatized to obtain the corresponding pyrimidinethione derivatives. The synthesized compounds were characterized by spectroscopic techniques like FT-IR, 1H NMR, 13C NMR, and mass spectrometry. These compounds were subjected to initial screening for their bioactivity using zone of inhibition method and were found moderately active against the tested microorganisms, viz. Mycobacterium smegmatis, Staphylococcus aureus, Escherichia coli, and Candida albicans.


Keyword:     Chalcones Pyrimidine derivatives Antimicrobial propertySpectral characterization.


Citation:

Shubhalaxmi, Manjunatha BS, Ananda K, Subrahmanya Bhat K. Pyrimidinethione derivatives with tosyl substitution: Synthesis, and antimicrobial property investigation. J App Pharm Sci, 2016; 6 (06): 073-078.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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