Research Article | Volume: 6, Issue: 6, June, 2016
Research Article | Volume: 6, Issue: 6, June, 2016
Substitution of tosyl group on hydroxyacetophenones orhydroxybenzaldehyde and their subsequent condensation yielded several tosyloxy substituted chalcones which were derivatized to obtain the corresponding pyrimidinethione derivatives. The synthesized compounds were characterized by spectroscopic techniques like FT-IR, 1H NMR, 13C NMR, and mass spectrometry. These compounds were subjected to initial screening for their bioactivity using zone of inhibition method and were found moderately active against the tested microorganisms, viz. Mycobacterium smegmatis, Staphylococcus aureus, Escherichia coli, and Candida albicans.
Shubhalaxmi, Manjunatha BS, Ananda K, Subrahmanya Bhat K. Pyrimidinethione derivatives with tosyl substitution: Synthesis, and antimicrobial property investigation. J App Pharm Sci, 2016; 6 (06): 073-078.
Year
Month
Synthesis and in vitro Anti Microbial Evaluation Including Anti-Malarial Activity of Pyrazole Based Novel Cinnoline Derivatives
3D-QSAR analysis of pyrimidine derivatives as AXL kinase inhibitors as anticancer agents
Antimicrobial properties of Ethiopian chewing sticks against Candida albicans
Kothai Seshathri