Research Article | Volume: 6, Issue: 6, June, 2016

Antibacterial activity of the major compound of an endophytic fungus isolated from Garcinia preussii

Jean-Bosco Joudaa Judith-Laure Demgne Fopossib Céline Djama Mbazoaa Jean Wandjia   

Open Access   

Published:  Jun 28, 2016

DOI: 10.7324/JAPS.2016.60605

Our research aimed at the chemical and biological investigations of selected endophytes associated with Garcinia preussii. The chemical investigation of the crude extract from the solid state fermentation of Aspergillus japonicus, an endophytic fungus harboring leaf of Garcinia preussii, by means of Liquid chromatography-Mass spectrometry (LC-MS) led to the isolation of two compounds. Their structures were elucidated on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature the isolated compounds were found to be variecolin (1) and neovasifuranone B (2) from the cyclohexane fraction. The antimicrobial studies showed that the isolated compounds exhibits antibacterial activity with inhibition zone diameters varying from 09.0±0.00 to 11.0±0.00 mm. These preliminary results showed promising activity of these compounds thus supporting the immensity of the potential of antibacterial drug discovery from miroorganisms.

Keyword:     Garcinia preussiiAspergillus sp.ophiobolinantibacterial.


Jouda JB, Fopossi JLD, Mbazoa CD, Wandji J. Antibacterial activity of the major compound of an endophytic fungus isolated from Garcinia preussii. J App Pharm Sci, 2016; 6 (06): 026-029.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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