Research Article | Volume: 5, Issue: 6, June, 2015

Chemical constituents from Piper caninum and antibacterial activity

Wan Mohd Nuzul Hakimi Wan Salleh Farediah Ahmad Khong Heng Yen   

Open Access   

Published:  Jun 27, 2015

DOI: 10.7324/JAPS.2015.50604
Abstract

Six flavonoids and two amides, characterized as 5,7-dimethoxyflavanone (1), 5,7-dimethoxyflavone (2), 4’,5,7-trimethoxyflavone (3), 4’-hydroxy-5,7-dimethoxyflavone (4), 5-hydroxy-7-methoxyflavone (5), 2’-hydroxy-4’,6’-dimethoxychalcone (6), N-isobutyl-(2E,4E,14Z)-eicosatrienamide (7) and N-isobutyl-15-(3’,4’-methylenedioxyphenyl)-2E,4E,12E-pentadecatrienamide (8) have been isolated and identified from the stem of Piper caninum. The identification of all compounds was achieved by physical properties and spectroscopically. These data were also confirmed by comparison with previously reported spectral data. Antibacterial activity of the extracts and isolated compounds was determined by disc diffusion method and minimum inhibitory concentration (MIC). All of the extracts displayed weak antibacterial activity against the tested bacteria. Compound (7) showed good activity towards Bacillis subtilis with MIC value of 125 μg/mL. Flavonoid compounds with high content in P. caninum can probably be used as a chemical marker for this Piper species.


Keyword:     FlavonoidsAmidesPiper caninumPiperaceaeAntibacterial.


Citation:

Wan Mohd Nuzul Hakimi Wan Salleh, Farediah Ahmad , Khong Heng Yen. Chemical constituents from Piper caninum and antibacterial activities. J App Pharm Sci, 2015; 5 (06): 020-025.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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