Research Article | Volume: 6, Issue: 6, June, 2016

Optimized gastroretentive floating carvedilol tablets: an approach for prolonged gastric residence time and enhanced absorption

Khalid El-Say   

Open Access   

Published:  Jun 28, 2016

DOI: 10.7324/JAPS.2016.60603
Abstract

Carvedilol (CVD) is an antihypertensive agent with short elimination half-life, pH-dependent solubility, and narrow absorption window. So, the present study aimed to prolong its gastric residence time that entailed a development of an optimized gastro retentive floating tablets (GRFTs) using 32full factorial design. The tablets were fabricated by direct compression using hydroxypropyl methylcellulose and carbopol 940 as release retarding polymers. The quality attributes of the tablets were evaluated. The buoyancy lag time, total floating time, swelling ability and in vitro release studies were also carried out in 0.1 N HCl (pH 1.2) at 37 ± 0.5 °C. Statistical data analysis revealed that the optimized formulation containing 21.91% HPMC and 15% carbopol 940 had acceptable hardness, optimum floating behavior and 24h controlled-release pattern. The design succeeded to develop CVD-GRFTs with floating ability and controlled release behavior that could improve its solubility, and improve its availability at the best absorptive site.


Keyword:     Floating tablet full factorial design optimization gastro retention.


Citation:

Khalid El-Say. Optimized gastroretentive floating carvedilol tablets: an approach for prolonged gastric residence time and enhanced absorption. J App Pharm Sci, 2016; 6 (06): 012-019.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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