Research Article | Volume : 2 Issue : 3, March 2012

Formulation and Evaluation of Gastroretentive Floating Tablets of Domperidone Maleate

D. Saritha,  D. Sathish,  Y. Madhusudan Rao   
D. Saritha, D. Sathish, Y. Madhusudan Rao

Center for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506 009, Andhra Pradesh, India.

Open Access    DOI: 10.7324/JAPS.2012.2311

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Abstract

The low bioavailability (15%) and good solubility of Domperidone Maleate in acidic pH following oral administration favours development of a gastro retentive formulation. Gastroretentive floating matrix tablets of Domperidone Maleate were successfully prepared with hydrophilic polymers like HPMC K4M, HPMC K15M and HPMC K100M. From the Preformulation studies for drug excipients compatibility it was observed that there was no compatability problem with the excipients used in study. The drug release from most of the formulations follows fickian diffusion. From in-vivo X-ray studies, it was clearly observed that the floating tablets showed a gastric residence of nearly 4.5 hrs in fed state.


Keyword:     Domperidone Maleatefloating tabletsgastric residence timegastroretentive drug delivery system.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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