Research Article | Volume: 6, Issue: 6, June, 2016

Physalis minima Linn Methanolic Extract Reduces Blood Glucose Level without Compromising Sperm Quality in Normoglycaemic Mice

Dzulsuhaimi Daud ,  Siti Fatimah Elias,  Fatimah Sarah Mohamad Hassan,  Mohammad Noor Jalil,  Alene Tawang   
Dzulsuhaimi Daud1 & 2, Siti Fatimah Elias2, Fatimah Sarah Mohamad Hassan3, Mohammad Noor Jalil3, Alene Tawang4

1Reproductive Biology & Toxicology Research Group, Pharmaceutical & Life Sciences Community of Research, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia.

2School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia.​​​​​​​

3School of Chemistry and Environment, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia.

4Department of Biology, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia.

Open Access   

Published:  Jun 28, 2016

DOI: 10.7324/JAPS.2016.60602
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Abstract

Effects of Physalis minima Linn (PML) methanolic extract on blood glucose level and sperm quality of normoglycaemic mice have been investigated. Twenty four ICR male mice were randomly assigned to four groups and fed with maintenance diets (commercial rat chow, 5 g/head/day and water ad-libitum). Group A (n=6) served as a control and received additional 2 ml/kg bodyweight (bwt) of distilled water. Group B, C and D were supplemented with 50, 100 and 200 mg/kg bwt of PML, respectively. Bodyweight and blood glucose level were monitored on a weekly basis. After four weeks of treatment, all animals were sacrificed by cervical dislocation and their epididymis was collected and subjected to sperm analysis. Bodyweight was increased (p<0.05) over time but no differences (p>0.05) were observed between treatments. Blood glucose was decreased significantly (p<0.05) in PML treated groups (dose dependent manner) compared to control. Sperm quality was not affected with PML supplementation. In conclusion, PML methanolic extract exhibit hypoglycaemic effect without affecting sperm quality in male mice.


Keyword:     Physalis minima sperm quality blood glucose diabetes mellitus.

Citation:

Daud D, Elias SF, Hassan FSM, Jalil MN, Tawang A. Physalis minima Linn Methanolic Extract Reduces Blood Glucose Level without Compromising Sperm Quality in Normoglycaemic Mice. J App Pharm Sci, 2016; 6 (06): 008-011.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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