Research Article | Volume: 6, Issue: 5, May, 2016

Evaluation of antipsychotic effect of methanolic extract of Ocimum sanctum leaves on laboratory animals

Kailash Sharma Milind Parle Monu Yadav   

Open Access   

Published:  May 28, 2016

DOI: 10.7324/JAPS.2016.60527
Abstract

Ocimum sanctum (Lamiaceae) commonly known as tulsi, is well known for its excellent nutritional and medicinal values throughout the world. The present study was undertaken to test the effect of methanolic extract of Ocimum sanctum leaves (50, 100 and 200mg/kg, p.o) on psychosis employing Ketamine induced stereotypic behaviour in mice and Pole climbing avoidance in rats. Haloperidol (1mg/kg, i.p.) and Olanzapine (5mg/kg, i.p.) are established antipsychotic drugs used as standard drugs in the present study. Effect of methanolic extract of Ocimum sanctum leaves (OS), on brain dopamine levels was also estimated. Methanolic extract of Ocimum sanctum leaves (50, 100 and 200mg/kg, p.o), significantly reduced the Ketamine induced falling, weaving, head bobbing and turning behavior in mice. Furthermore, it significantly delayed the latency time taken by the rats to climb the pole. Haloperidol (1mg/kg; i.p.) and Olanzapine (5mg/kg, i.p.) significantly reduced the Ketamine induced stereotypic behavior in mice and condition avoidance behavior in rats. Interestingly, Brain dopamine level was significantly reduced by methanolic extract of Ocimum sanctum leaves. These findings, when taken together indicate that methanolic extract of Ocimum sanctum leaves possesses anti-psychotic like property.


Keyword:     Psychosis anti-psychotics Ocimum sanctum tulsi.


Citation:

Sharma K, Parle M, Yadav M.,Evaluation of antipsychotic effect of methanolic extract of Ocimum sanctum leaves on laboratory animals. J App Pharm Sci, 2016; 6 (05): 171-177.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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