Research Article | Volume: 6, Issue: 5, May, 2016

Synthesis, spectral aspects and biological activities of 5-hydroxy-2-nitrobenzaldehydethiosemicarbazone and their Mn(II), Co(II) and Ni(II) complexes

M. Sivasankar Reddya,  B. Prathimaa,  M. Saraswathib,  S. Babuc,  Y. Saralad,  A. Varada Reddya   
M. Sivasankar Reddya, B. Prathimaa, M. Saraswathib, S. Babuc, Y. Saralad, A. Varada Reddya

aDepartment of Chemistry, Sri Venkateswara University, Tirupati-517 502, India.

bDepartment of Applied Microbiology, Sri Padmavathi Mahila Visvavidyalayam, Tirupati-517502, India.

cDepartment of Physics, Sri Venkateswara University, Tirupati-517 502, India.

dDepartment of chemical engineering, CBIT, Gandipet, Hyderabad-500 075, India.

Open Access   

Published:  May 28, 2016

DOI: 10.7324/JAPS.2016.60514
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Abstract

The ligation behavior of 5-hydroxy-2-nitrobenzaldehydethiosemicarbazone (L) and its Mn(II), Co(II) and Ni(II) complexes has been synthesized and characterized by Elemental analysis, Electronic, FT-IR, Raman, EPR spectral techniques and Cyclic voltammetric study. The ligand (L) belongs to triclinic system with P1 space group. The IR spectral data of ligand indicate the taking part of sulphur and azomethine nitrogen in coordination to the central metal ion. The electronic, FT-IR and EPR spectral studies reveals all the complexes are distorted octahedral geometry. The synthesized ligand and its metal(II) complexes were tested for their antioxidant activity by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method and antibacterial activity against E.coli, Staphylococcus aureus, Bacillus subtilis, Salmonella typhi and Klebsiella pneumonia. The antibacterial and antioxidant activities of the ligand and its metal complexes had shown moderate to good activity, among all the compounds Ni(II) complex had shown more activity.


Keyword:     Thiosemicarbazone Raman EPR Octahedral geometry Biological studies.

Citation:

Reddy MS, Prathima B, Saraswathi M, Babu S, Sarala Y, Reddy AV. Synthesis, spectral aspects and biological activities of 5- hydroxy-2-nitrobenzaldehydethiosemicarbazone and their Mn(II), Co(II) and Ni(II) complexes. J App Pharm Sci, 2016; 6 (05): 090- 096.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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