Research Article | Volume: 6, Issue: 5, May, 2016

Phytochemistry and in vitro Antimicrobial, Antioxydant Activities of Entandrophragma candollei H.

Nnanga NGA ,  ,  ,  Vandi Deli,  Famen NDEL Louis Claire,  SIDJUI SIDJUI Lazare ,  ,  SIKADEU Sandrine,  NGUE Samuel Arthur,  Toghueo Kouipou Rufin Marie,  Nganso DITCHOU Yves Oscar,  MPONDO MPONDO Emmanuel ,    
Nnanga NGA1 , 2 , 3, Vandi Deli3, Famen NDEL Louis Claire3, SIDJUI SIDJUI Lazare1 , 4, SIKADEU Sandrine3, NGUE Samuel Arthur3, Toghueo Kouipou Rufin Marie5, Nganso DITCHOU Yves Oscar6, MPONDO MPONDO Emmanuel2 , 3

1Institute of Medical Research and Medicinal Plants Studies P.O Box 6163 Yaoundé, Cameroon.

2Department of Galenic and Legislation, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, P.O Box: 337Yaoundé, Cameroon.

3Department of Pharmacy, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, P.O Box: 2701 Douala, Cameroon.

4Departments of Organic Chemistry, University of Yaoundé I, P.O Box 812, Yaoundé, Cameroon.

5Departments of Biochemistry, University of Yaoundé I, Cameroon.

6Department of Chemistry, Faculty of Sciences, University of Maroua, Maroua, Cameroon.

Open Access   

Published:  May 28, 2016

DOI: 10.7324/JAPS.2016.60512
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Abstract

The research work was conducted to investigate the in vitro antimicrobial and antioxidant activity of extract of E. candollei (Family-Meliaceae). Phytochemical screening was done. Disc diffusion technique was used for in vitro antibacterial and antifungal screening. Minimal inhibitory concentration of promising extracts was determined by broth microdilution method. The phytochemical screening showed the presence of flavonoids compounds, tannins and saponins. The inhibition diameters were ranging from 7 to 17 mm and Minimum Inhibitory Concentrations (MIC) from 156.25 to 2500 µg/mL. The ethyl acetate and ethanolic extract revealed a high radical scavenging activity with IC50 ranging from 9.1026 to 11.8298 µg/mL. The Ferric reducing power activity was obtained with active concentration ranging from 12.5 to 200 µg/mL. These results suggest that extracts from E. candollei possess antibacterial and antioxidant activities and therefore justifies their usage in traditional medicine for the treatment of various diseases.


Keyword:     Entandrophragma candollei antioxidant antimicrobial activity.

Citation:

Nnanga N, Vandi D, Famen LN, Sidjui LS, Ngué SA, Sikadeu S, Toghueo RMK, Nganso YOD, Mpondo EM. Phytochemistry and in Vitro Antimicrobial, Antioxydant Activities of Entandrophragma Candollei H. J App Pharm Sci, 2016; 6 (05): 073-079.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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