Research Article | Volume: 6, Issue: 4, April, 2016

Impact of Chrysanthemum fontanesii extract on sodium valproate mediated oxidative damage in mice kidney

Amel Amrani ,  ,  Ouahiba Benaissa,  Nassima Boubekri ,  ,  Kenza Biod,  Radja Djabari,  Nawal Beroal,  Djamila Zama ,  ,  Fadila Benayache,  Samir Benayache   
Amel Amrani1 , 2, Ouahiba Benaissa1, Nassima Boubekri1 , 2, Kenza Biod2, Radja Djabari2, Nawal Beroal2, Djamila Zama1 , 2, Fadila Benayache1, Samir Benayache1

1Unité de Recherche Valorisation des Ressources Naturelles, Molécules Bioactives, Analyses Physicochimiques et Biologiques (VARENBIOMOL), Université frères Mentouri Constantine, Route de Aïn El Bey, 25000 Constantine, Algérie.

2Departement de Biologie Animale; Faculté des SNV. Université frères Mentouri Constantine, Route de Aïn El Bey, 25000 Constantine, Algérie.

Open Access   

Published:  Apr 30, 2016

DOI: 10.7324/JAPS.2016.60409
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Abstract

The objective of this study was to evaluate the potential of n-butanol extract obtained from flowers of Chrysanthemum fontanesii (Cf) and vitamin E against kidney oxidant injury induced by sodium valproate in mice. The evaluation was made through Histopathological examination and measuring kidney lipid peroxidation (LPO) and antioxidant parameters: reduced glutathione (GSH), glutathione peroxidase (GPx) and catalase. Severe alterations in all biomarkers were observed after injury with VPA. Treatment with Cf extract and vitamin E resulted in markedly decreased levels of LPO while increased levels of GSH and antioxidant enzymes activities were observed. In conclusion, n-butanol extract of Cf may be an interesting candidate for the treatment of kidney injury induced by VPA through enhancing endogenous antioxidant defenses and normalizing the kidney histopathological architecture.


Keyword:     Valproic acid Chrysanthemum fontanesii kidney oxidant injury Antioxidant Renoprotective effect.

Citation:

Amrani A, Benaissa O, Boubekri N, Biod K, Djebari R, Beroal N, Zama D, Benayache F, Benayache S. Impact of Chrysanthemum fontanesii extract on sodium valproate mediated oxidative damage in mice kidney. J App Pharm Sci, 2016; 6 (04): 067-071.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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