Review Article | Volume: 6, Issue: 3, March, 2016

Recent Advances and Future Prospects of Phthalimide Derivatives

Neelottama KushwahaDarpan Kaushik   

Open Access   

Published:  Mar 30, 2016

DOI: 10.7324/JAPS.2016.60330
Abstract

Among bicyclic non-aromatic nitrogen heterocycles, phthalimides are an interesting class of compounds with a large range of applications. Phthalimide contains an imide functional group and may be considered as nitrogen analogues of anhydrides or as diacyl derivatives of ammonia. They are lipophilic and neutral compounds and can therefore easily cross biological membranes in vivo and showing different pharmacological activities. In the present work compounds containing phthalimide subunit have been described as a scaffold to design new prototypes drug candidates with different biological activities and are used in different diseases as, for example AIDS, tumor, diabetes, multiple myeloma, convulsion, inflammation, pain, bacterial infection among others.


Keyword:     Phthalimide derivativesimidebiological activity.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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