Research Article | Volume: 5, Supplement: 3, November, 2015

Synthesis and screening of new maleimide derivatives as potential anti-tubercular agents

Saroj Kumar Sahooa Kurre Purna Nagasreeb Jamullamudi Risy Namrathab Pemmadi Raghuveer Varmab Muthyala Murali Krishna Kumarb   

Open Access   

Published:  Nov 12, 2015

DOI: 10.7324/JAPS.2015.510.S8

In the present investigation a series of new maleimide derivatives were synthesized by reacting different anilines with maleic anhydride in presence of acetic anhydride and sodium acetate. The synthesized compounds were identified by using IR, 1H NMR and mass spectral data analysis. The preliminary in vitro antimicrobial activity was studied against S. aureus, E. coli and A. niger. Further, the synthesized compounds (PA1-PA15) were subjected to in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv using MABA method. The compounds PA4 (MIC 6.25 µg/ml), PA8 (MIC 3.125 µg/ml), PA14 (MIC 3.125 µg/ml) showed significant inhibitory activity against M. tuberculosis H37Rv.

Keyword:     Maleimide antitubercular 34-diarylpyrrole denigrin tuberculosis.


Saroj Kumar Sahoo, Kurre Purna Nagasree, Jamullamudi Risy Namratha, Pemmadi Raghuveer Varma, Muthyala Murali Krishna Kumar. Synthesis and screening of new Maleimide derivatives as potential Anti-Tubercular agents. J App Pharm Sci, 2015; 5 (Suppl 3): 044-047.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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