Research Article | Volume: 6, Issue: 3, March, 2016

Composition, antioxidant and antimicrobial activities of Eleutherococcus senticosus fruit extracts

Daehan JangJunwoo LeeSeung Hee EomSeung Min LeeJinsu GilHeung Bin LimTae Kyung Hyun   

Open Access   

Published:  Mar 30, 2016

DOI: 10.7324/JAPS.2016.60322
Abstract

This study was designed to examine the in vitro antioxidant and antimicrobial activities of essential oil and crude methanolic (MeOH) extract of Eleutherococcus senticosus (common name, Siberian ginseng) fruit and its partitioned fractions, including hexane, ethyl acetate (EtOAc), n-butanol (BuOH) and aqueous. 1,1-dephenyl-2-picryl-hydrazyl free radical scavenging and reducing power assay suggest that antioxidant activity of EtOAc and BuOH fractions is due to the reducing ability of the antioxidant against oxidative effects of reactive oxygen species. In addition, the essential oil of Siberian ginseng fruit showed remarkable antimicrobial activity against Kocuria rhizophila (MIC = 125 µg/ml), Micrococcus luteus (MIC = 500 µg/ml), and Escherichia coli (MIC = 63 µg/ml). The chemical compositions of the essential oil obtained by the simultaneous steam-distillation and extraction method were analyzed using GC-MS; trans-caryophyllene (21.7%), humulene (7.4%), bicyclogermacrene (6.0%), (+) spathulenol (4.5%), germacrene-D (3.2%), tau-muurolol (2.5%) and delta-cadinene (2.3%) were found as main constituents. Furthermore, HPLC analysis identified ursolic acid as one of the principal components in Siberian ginseng fruit extract. Although this study has been carried out by in vitro assay, these results suggest that Siberian ginseng fruit may be a good candidate as a source of antioxidant and antimicrobial ingredients.


Keyword:     Eleutherococcus senticosusEssential oilAntioxidantAntimicrobialUrsolic acid.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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