Research Article | Volume: 6, Issue: 3, March, 2016

Molar Refraction and Polarizability of Antiemetic drug 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2 methoxybenzamide hydrochloride monohydrate in {Aqueous-Sodium or Lithium Chloride} Solutions at 30 °C

Rajendrakumar T. SawaleTukaram M. KalyankarRoy GeorgeSantosh D. Deosarkar   

Open Access   

Published:  Mar 30, 2016

DOI: 10.7324/JAPS.2016.60321

The 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2 methoxybenzamide hydrochloride monohydrate exhibits antiemetic and parasympathomimetic activity. Density (ρ) and refractive index (nD) measurements were carried out as a function of drug concentration (c=0.01-0.11 mol•L-1) in aqueous NaCl/LiCl (c=0.05, 0.10 and 0.15 mol•L-1) solutions at 30 °C. Linear relation of concentration dependence of density and refractive index were studied. Molar refractivity (Rm) of solution was calculated from density and refractive index data and polarizability (α) was calculated from molar refractivity data. Stronger polarizability effects have been observed with increase in drug concentration.

Keyword:     DensityPhysicochemical propertiesMolecular interactionsPolarizability.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

HTML Full Text


Article Metrics
350 Views 36 Downloads 386 Total



Related Search

By author names