Research Article | Volume: 6, Issue: 3, March, 2016

Association of Glycated Albumin with Glycemic Markers, Lipid Profile and Liver Function Tests for the Assessment Control in Saudi Patients with Long-Standing Type-2 Diabetes Mellitus

Saifeldeen Babiker AbdallaSiddig Ibrahim Abelwahab   

Open Access   

Published:  Mar 30, 2016

DOI: 10.7324/JAPS.2016.60316
Abstract

This study is an effort to evaluate the association between glycated-albumin and various biochemical parameters in Saudi type-2 diabetic patients. Ninety long-standing (>10 years) type-2 diabetic subjects (51 males, 39 females) serum was analyzed for glycated albumin, fasting blood glucose, hemoglobin1c, cholesterol, triglyceride, albumin, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, aspartate transaminase, alkaline phosphatase, alanine transaminase and total bilirubin. Correlation, principal components analysis, covariance and statistical differences were conducted using SPSS for both male and female participants. The average age (years) of female and male participants was 51.0±10.2 and 51.6±14.1, respectively. Hemoglobin1C was significantly associated with fasting blood glucose (r=0.637,P<0.01). No significant differences between men and women were observed in the glycemic markers, lipid profile and liver function tests. Both men and women showed no significant differences in glycated-albumin irrespective of age and hemoglobin1c covariance. The regression model revealed that low-density lipoprotein, aspartate transaminase and alanine transaminase are significantly associated with glycated-albumin. Men’s glycated-albumin was observed to be significantly associated with hemoglobin1c only, while women’s glycated-albumin is highly associated with low-density lipoprotein only. Glycated-albumin was also co-varied with low-density lipoprotein. Glycated-albumin could be employed for screening high risk diabetic patients for early diagnosis of dyslipidemia and appropriate intervention with lipid-decreasing drugs. Current findings provide novel insights on the use glycated-albumin as clinical chemistry maker.


Keyword:     Glycated albumin Diabetes mellitusSaudi Arabia.


Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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