Research Article | Volume: 6, Issue: 2, February, 2016

Antinociceptive, anti-inflammatory and antipyretic effects of ethanolic root bark extract of Icacina senegalensis in rodents

Esien David-Oku Godwin Christian Akuodor Emmanuel Effiong Edet Godknows K Ogbuji Juliet Ifeoma Obiajunwa-Otteh Daniel Ogbonna John Aja   

Open Access   

Published:  Feb 27, 2016

DOI: 10.7324/JAPS.2016.60215
Abstract

To investigate the ethanolic root bark extract of Icacina senegalensis for antinociceptive, anti-inflammatory and antipyretic activities in rats and mice. Acetic acid-induced abdominal constriction and tail immersion tests were used to evaluate the antinociceptive activity of the extract. Egg albumin and carrageenan-induced paw oedema were used to study the anti-inflammatory activity, whereas the anti-pyretic studies were evaluated on yeast and amphetamine-induced pyrexia. The root bark extract (50, 100 and 200 mg/kg) significantly (P<0.05) showed inhibitory activity for all the models in the antinociceptive, anti-inflammatory and antipyretic assayed. Result shows that ethanolic root bark extract of Icacina senegalensis possesses phytochemicals with therapeutic potential against painful, inflammatory and feverish conditions, and thus explain the use of Icacina senegalensis for similar ailments in traditional medicine.


Keyword:     Icacina senegalensis root pain inflammationfever; rats mice.


Citation:

David-Oku E, Akuodor GC, Edet EE, Ogbuji GK, Obiajunwa-Otteh JI, Aja DOJ. Antinociceptive, anti-inflammatory and antipyretic effects of ethanolic root bark extract of Icacina senegalensis in rodents. J App Pharm Sci, 2016; 6 (02): 104-108.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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