Research Article | Volume: 6, Issue: 2, February, 2016

The Median Time to Develop Recurrent Tuberculosis at a Tertiary Hospital in Kota Bharu, Kelantan, Malaysia

Nyi Nyi Naing,  Myat Moe Thwe Aung,  Abdullah Mohamed Rusli,  Mat Jaeb Mat Zuki,  Nadiah Wan-Arfah,  Mainul Haque   
Nyi Nyi Naing1, Myat Moe Thwe Aung2, Abdullah Mohamed Rusli3, Mat Jaeb Mat Zuki4, Nadiah Wan-Arfah1, Mainul Haque5

1Unit of Biostatistics and Research Methodology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

2Universiti Sultan Zainal Abidin (UniSZA), Faculty of Medicine and Health Sciences (FPSK), Jalan Sultan Mahmud 20400, Kuala Terengganu, Terengganu, Malaysia.

3Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.

4Respiratory Specialist, Chest Clinic, Department of Medicine, Hospital Raja Perempuan Zainab II, 15000 Kota Bharu, Kelantan, Malaysia.

5Unit of Pharmacology, FPSK, UniSZA, 20400 Kuala Terengganu, Terengganu, Malaysia.

Open Access   

Published:  Feb 27, 2016

DOI: 10.7324/JAPS.2016.60214
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Abstract

This study has the intention to determine the median time to develop recurrent tuberculosis [TB] in TB patients attending the Chest Clinic at Hospital Raja Perempuan Zainab II [HRPZ II], Kelantan, Malaysia. Records of 114 recurrent TB patients from 1/1/2003-31/12/2009 were analyzed. Kaplan-Meier analysis was used to examine the median time for recurrence of TB. The overall median time to develop TB recurrence in registered TB recurrent patients was six months [95%CI: 4.58, 7.42] after the previous episode. It was found that recipients of Streptomycin (S), Isoniazid (H) and Rifampicin (R) twice weekly (S2H2R2) drug regimen [p=0.026] or daily HR drug regimen [p=0.049] during the continuation phase took a longer duration to develop recurrent TB than non-recipients of these medicines by Kaplan-Meier analysis. Moreover, there also existed a significant time difference [P = 0.006] between the defaulters and non-defaulters of treatment to develop recurrent TB. Patients should take the complete course of therapy, to reduce recurrent TB infection. The drug regimens must contain the two most potent first line drugs Isoniazid [H] and Rifampicin [R] during the continuation phase.


Keyword:     Tuberculosis Kaplan-Meier Median time Recurrent Malaysia.

Citation:

Naing NN, Aung MMT, Rusli AM, Zuki MJM, Arfah NW, Haque M. The Median Time to Develop Recurrent Tuberculosis at a Tertiary Hospital in Kota Bharu, Kelantan, Malaysia. J App Pharm Sci, 2016; 6 (02): 097-103.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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