Research Article | Volume: 6, Issue: 2, February, 2016

Antimicrobial and Anticancer Activities of Ethyl Acetate Extract of Co-culture of Streptomyces sp. ANAM-5 and AIAH-10 Isolated From Mangrove Forest of Sundarbans, Bangladesh

Md. Uzzal Haque,  Md. Ajijur Rahman,  Md. Anwarul Haque,  Ashish Kumar Sarker,  Md. Anwar Ul Islam   
Md. Uzzal Haque1, Md. Ajijur Rahman2, Md. Anwarul Haque3, Ashish Kumar Sarker3, Md. Anwar Ul Islam2

1Department of Pharmacy, Faculty of Biological Science and Technology, Jessore University of Science and Technology, Jessore-7408, Bangladesh.

2Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi-6205, Bangladesh.

3Department of Pharmacy, Faculty of Science, Pabna University of Science and Technology, Pabna-1234, Bangladesh.

Open Access   

Published:  Feb 27, 2016

DOI: 10.7324/JAPS.2016.60207
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Abstract

In this study we investigated the antimicrobial and anticancer activities of ethyl acetate extract of co-culture of Streptomyces sp. ANAM-5 and AIAH-10 isolated from soil of mangrove forest Sundarbans, Bangladesh. The antimicrobial activity of ethyl acetate extract was determined using broth-dilution method against Candida albicans, Saccharromyces cerevaceae and Aspergillus niger whereas anticancer activity was evaluated against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice with the dose of 50 mg/kg and 100 mg/kg body weight (i.p). The Minimum Inhibitory Concentrations (MIC) of ethyl acetate extract was found 32μg/ml against Candida albicans while 64 μg/ml against Saccharromyces cerevaceae and Aspergillus niger. The antineoplastic activity of the crude extract was increased in dose dependent manner with a significant value (p<0.01). Bacterial crude extract enhanced the mean survival time (MST) of tumor bearing mice at 71.79% and maximum cell growth inhibition was found 75.75 % with dose of 100 mg/kg body weight (i.p.). Our study revealed that ethyl acetate extract of co-culture of Streptomyces sp. ANAM-5 and AIAH-10 is an excellent source of antimicrobial and anticancer compounds which may become helpful to treat infections and cancer.


Keyword:     Mixed fermentation Streptomyces sp. MIC MFC anticancer activity.

Citation:

Haque MU, Rahman MA, Haque MA, Sarker AK, Islam MAU. Antimicrobial and Anticancer Activities of Ethyl Acetate Extract of Co-culture of Streptomyces sp. ANAM-5 and AIAH-10 Isolated From Mangrove Forest of Sundarbans, Bangladesh. J App Pharm Sci, 2016; 6 (02): 051-055.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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