Research Article | Volume: 5, Supplement: 3, November, 2015

Development of thermo-sensitive poly N-isopropyl acrylamide grafted chitosan derivatives

Tamer M. Tamer,  Ahmed M. Omer,  Mohamed A. Hassan,  Mohamed E. Hassan ,  ,  Maysa M. Sabet,  Mohamed S. Mohy Eldin   
Tamer M. Tamer1, Ahmed M. Omer1, Mohamed A. Hassan2, Mohamed E. Hassan3 , 4, Maysa M. Sabet1, Mohamed S. Mohy Eldin5

1Polymer Materials Research Department, Advanced Technologies and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P.O. Box: 21934 Alexandria, Egypt.

2Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P.O. Box: 21934 Alexandria, Egypt.

3Center of Excellence, Encapsulation & Nanobiotechnology Group, National Research Center, El-Behouth Street, Cairo 12311, Egypt.

4Chemistry of Natural and Microbial Products Department, National Research Center, El Behouth Street, Cairo 12311, Egypt.

5Chemistry Department, Faculty of Science, University of Jeddah, Osfan, P. O. Box: 80203, Jeddah 21589, Saudi Arabia.

Open Access   

Published:  Nov 12, 2015

DOI: 10.7324/JAPS.2015.510.S1
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Abstract

In this study, the thermo-sensitive copolymers were synthesized by graft copolymerization of poly N isopropyl acrylamide (PNIPAm) onto chitosan (Ch) and aminated chitosan (AmCh) derivative. Free radical polymerization using potassium persulphate (KPS) as initiator was used for performing the grafting process. FTIR, TGA and DSC analysis were used to verify the structure of the resulting graft copolymers. The thermal sensitivity of the prepared copolymers was determined by monitoring the phase transition temperature at 550nm using a UV–VIS spectrophotometer. The results show that the transition of the PNIPAm-g-Ch is sharper than that of the PNIPAm-g-AmCh and the tr-ansition, in both cases, became sharper as increase the PNIPAm grating percentage.


Keyword:     Chitosan Aminated chitosan poly N- isopropylacrylamide Thermo-sensitive.

Citation:

Tamer Mahmoud Tamer, Ahmed Mahmoud Omer, Mohamed Adel Hassan, Mohamed Elsayed Hassan, Maysa mohamed sabet, Mohamed Samir Mohy Eldin. Development of thermo-sensitive poly N-isopropyl acrylamide grafted chitosan derivatives. J App Pharm Sci, 2015; 5 (Suppl 3): 001-006.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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