Short Communication | Volume: 5, Issue: 10, October, 2015

Antimicrobial activity of endophytic fungi from marine Sponge Haliclona fascigera

Dian Handayani Rizka Fauza Ahdinur R. Rustini   

Open Access   

Published:  Oct 28, 2015

DOI: 10.7324/JAPS.2015.501027

Fungi associated with marine sponge Haliclona fascigera has shown a promising source in the search for new antimicrobial compounds. We have isolated 25 endophytic fungi from the sponge, which were cultured in Sabouraud Dextrose Broth (SDB) for 4 weeks at 25-27 ºC. The ethyl acetate extracts of the isolates-broth were then tested for its antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans by using agar diffusion method. The zone of inhibition was measured and expressed in millimeters. There were 8 isolates of the fungi that considered active to Staphylococcus aureus, i.e. HF2 isolate (14,5 mm), HF8 isolate (12,5 mm), HF9 isolate (14 mm), HF13 isolate (16,5 mm), HF14 isolate (11 mm), HF19 isolate (14,5 mm), HF21 isolate (14,5 mm), HF22 isolate (13 mm), and 1 isolate active to C. albicans, i.e. HF16 isolate (12,5 mm). The identification of the bioactive fungi isolates was done by comparing its macroscopic and microscopic characteristic based on literature. From the study, it can be concluded that fungi associated with marine sponge Haliclona fascigera possesses potentially antimicrobial activity which might be due to the presence of bioactive metabolite compounds.

Keyword:     Antimicrobial activity Marine sponge Haliclona fascigera Endophytic fungi.


Dian Handayani, Rizka Fauza Ahdinur, Rustini Rustini. Antimicrobial activity of endophytic fungi from marine Sponge Haliclona fascigera. J App Pharm Sci, 2015; 5 (10): 154-156.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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