Review Article | Volume: 5, Issue: 7, July, 2015

Progress in Brain Delivery of Anti-HIV Drugs

Malay K Das Tapash Chakraborty   

Open Access   

Published:  Jul 27, 2015

DOI: 10.7324/JAPS.2015.50724
Abstract

The HIV/AIDS pandemic is an increasing global burden with devastating health-related and socioeconomic effects. The widespread use of antiretroviral therapy has dramatically improved life quality and expectancy of infected individuals. But currently available drug regimens and dosage forms are not good enough to eradicate HIV. Suboptimal adherence, toxicity, drug resistance and viral reservoirs make the lifelong treatment of HIV infection challenging. Along with some other organs, highly vascularized and secured with blood-brain barrier (BBB), brain acts as a great reservoir for the HIV virus. But all the available drug delivery techniques are not capable of bypassing the BBB and deliver anti-HIV drugs to the brain. In this review, all the brain delivery techniques available till date has been reviewed and recent noble ideas for delivering anti-HIV drugs to brain has been discussed.


Keyword:     Brain targeting Anti-HIV nanoparticles liposomes SLN NLC.


Citation:

Malay K Das, Tapas Chakraborty. Progress in Brain Delivery of Anti-Hiv Drugs. J App Pharm Sci, 2015; 5 (07): 154-164.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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