Research Article | Volume: 5, Issue: 6, June, 2015

In-vitro Assessment of Effectiveness and Photostability Avobenzone in Cream Formulations by Combination Ethyl Ascorbic acid and alpha Tocopherol Acetate

Marline Abdassah Ratih Aryani Emma Surachman Muchtaridi Muchtaridi   

Open Access   

Published:  Jun 27, 2015

DOI: 10.7324/JAPS.2015.50611
Abstract

Avobenzone is UVA sunscreen active substances, which are unstable when exposed to UV radiation, especially UVA. Theaim of this study is to determine the effectiveness and photo stability avobenzone when combined with ethyl ascorbic acid and alpha tocopherol acetate with various concentrations of ethyl ascorbic acid and alpha tocopherol by in vitro using spectrophotometric method. The photostability study of the eight variations of formula showed that the formula3, 4, 5, 6, 7 and 8 had significant differences with Formula 1 (p<0,05) and the best photostability represented by the formula 4 (avobenzone 2%, ethyl ascorbic acid2%) with avobenzone concentrations decrease by 11,82% for 15 hour using UVA lamp irradiation 4,7 mW/cm2. In effectiveness of SPF (Sun Protection Factor) value determination showed moderate protection category (SPF ±6). The percent transmission of erythema and pigmentation test showed that cream had effectiveness as sunscreen by showing the category as sun block on the area pigmentation and not to erythema areas at concentration 1000 µg/ml.


Keyword:     UVA SPF (Sun Protecting Factor) erythema transmission pigmentation transmission.


Citation:

Marline Abdassah, Ratih Aryani, Emma Surachman, Muchtaridi Muchtaridi. In-vitro Assessment of Effectiveness and Photostability Avobenzone In Cream Formulations By Combination Ethyl Ascorbic acid and alpha Tocopherol Acetate. J App Pharm Sci, 2015; 5 (06): 070-074.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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