Research Article | Volume: 5, Issue: 4, April, 2015

Development of oral capsules from Enterica herbal decoction-a traditional remedy for typhoid fever in Ghana

Doris Kumadoh ,  Joseph Adotey ,  Kwabena Ofori-Kwakye,  Samuel Lugrie Kipo,  Thomford Prah,  Sowah Patterson   
Doris Kumadoh1 3, Joseph Adotey2 3, Kwabena Ofori-Kwakye3, Samuel Lugrie Kipo3, Thomford Prah1, Sowah Patterson1

1Centre for Scientific Research into Plant Medicine (CSRPM), P.O. Box 73, Mampong-Akwapim, Ghana.

2Department of Pharmaceutical Science, School of Applied Sciences, Central University College, Miotso, Ghana;

3Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Open Access   

Published:  Apr 27, 2015

DOI: 10.7324/JAPS.2015.50414
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Abstract

The study aimed to develop oral capsules from Enterica herbal decoction used in Ghana for the treatment of typhoid fever and produced by the Centre for Scientific Research into Plant Medicine (CSRPM). The amount of dry extract per dose (30ml) of Enterica and the wavelength of maximum absorption (λmax) of aqueous solutions of Enterica extract were determined. Light magnesium carbonate (LMC) and maize starch (MS) were employed as absorbents at various concentrations in the preparation of granules of the extract. The % loss in weight, size distribution and flow properties of the granules were evaluated. Enterica oral capsules were formulated using LMC at 22 mg/dose of extract and the dissolution properties of the granules and capsules were determined by UV-VIS spectrophotometry. The dry Enterica extract/dose was 190.1 ± 0.12 mg and λmax was 356 nm. The loss of granules was 2.07-7.31 %w/w for LMC and 2.73-7.81 %w/w for MS. LMC granules (22 mg/dose) prepared for encapsulation exhibited good flow properties. The granules for encapsulation exhibited optimal release of extract (86.08 ± 1.64 % at 45 min) in aqueous medium. The formulated capsules passed the British Pharmacopoeia uniformity of weight, disintegration and dissolution tests. Enterica oral capsules can be used as a substitute for Enterica decoction for the treatment of typhoid fever.


Keyword:     Herbal medicine Herbal extracts Absorbents Herbal capsules Maize starch Light magnesium carbonate.

Citation:

Kumadoh D., Adotey J., Ofori-Kwakye K., Kipo S. L., Prah T., Patterson S. Development of oral capsules from Enterica herbal decoction-a traditional remedy for typhoid fever in Ghana. J App Pharm Sci, 2015; 5 (04): 083-088.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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