Research Article | Volume: 5, Issue: 3, March, 2015

Cell viability, anti-proliferation and antioxidant activities of Sideritis syriaca, Tanacetum argenteum sub sp. argenteum and Achillea aleppica subsp. zederbaueri on human breast cancer cell line (MCF-7)

Onder Yumrutas,  Serdar Oztuzcu,  Mustafa Pehlivan,  Nilgun Ozturk,  I. Eroz Poyraz,  Yusuf Ziya IÄŸci,  M. Ozgur Cevik,  Ibrahim Bozgeyik,  Ayse Fatma Aksoy,  Haydar Bagıs ,  Ahmet Arslan   
Onder Yumrutas1, Serdar Oztuzcu2, Mustafa Pehlivan3, Nilgun Ozturk4, I. Eroz Poyraz5, Yusuf Ziya Iğci2, M. Ozgur Cevik6, Ibrahim Bozgeyik1, Ayse Fatma Aksoy2, Haydar Bagıs6 , Ahmet Arslan2

1University of Adiyaman, Faculty of Medicine, Department of Medical Biology, Adiyaman, Turkey.

2University of Gaziantep, Faculty of Medicine, Department of Medical Biology, Gaziantep, Turkey.

3University of Gaziantep, Faculty of Science and Art, Department of Biology, Gaziantep, Turkey.

4University of Anadolu, Faculty of Pharmacy, Department of Pharmacognosy, Eskisehir, Turke.

5University of Anadolu, Faculty of Pharmacy, Department of Pharmaceutical Botany, Eskisehir,Turkey. 6University of Adiyaman, Faculty of Medicine, Department of Medical Genetic, Adiyaman, Turkey.

Open Access   

Published:  Mar 28, 2015

DOI: 10.7324/JAPS.2015.50301
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Abstract

The breast cancer is one of the most common types of cancer. Many scientists have focused on the treatment of this disease for a long time by studying anti-cancer activities of plant extracts as well as synthetics. Lamiaceae and Asteraceae have been used in anticancer studies due to their phytochemical content. The genus Sideritis, Achillea and Tanacetumare the members of these families. Sideritis, Achillea and Tanacetum are used as herbal medication for the treatment of variety of diseases. In present study, we demonstrated the biological activity of Sideritis syriaca (SS), Achillea aleppica (AAZ) and Tanacetum argenteum (TAA) methanol extracts on cell viability of the breast cancer line MCF7. MTT (3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay was used to determine the cell viability and proliferation of MCF7 cells. In a dose dependent manner, methanol extracts (0, 1, 5, 25, 100 and 250 µg/ml) of SS, AZZ and TAA were examined on MCF7, and viability of cells were determined with MTT staining. Especially, concentrations in 100 and 250 µg/ml of extracts decreased the cell viability (p


Keyword:     Cancer cell lineCell viabilityAntiproliferationAntioxidantSideritisTanacetumAchillea.

Citation:

Onder Yumrutas, Serdar Oztuzcu, Nilgun Ozturk, Mustafa Pehlivan I. Eroz Poyraz, Ibrahim Bozgeyik, Yusuf ZiyaIğci, M. Ozgur Cevik, Ayse Fatma Aksoy, Haydar Bagıs, Ahmet Arslan. Cell viability, anti-proliferation and antioxidant activities of Sideritis syriaca, Tanacetum argenteum subsp. argenteum and Achillea aleppica subsp. zederbaueri on human breast cancer cell line (MCF-7). J App Pharm Sci, 2015; 5 (03): 001-005.

Copyright:The Author(s). This is an open access article distributed under the Creative Commons Attribution Non-Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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